Presently, the treatment of antibiotic resistant pathogenic bacteria has been extensively performed worldwide. The evolution of pathogenic bacteria against commercially available antimicrobial agents has become a critical problem in modern era. Phage therapy could be used as a potential alternative to antibiotics. Soviet Union used bacteriophages to treat infected soldiers during Second World War. Afterwards the Russian researchers started to work on the development of treatment via different Bacteriophages and further US researcher was actively involved on phase therapy and approached towards commercialization of phase therapy. Naturally occurring antibacterial agents are not able to overcome bacterial resistance, while Bacteriophages have a higher mutation and replication rate, so they can compete over the development of resistance of bacteria against antimicrobial agents.