Helicobacter pylori (H.pylori) infection is endemic in Iraq and important cause of gatrointestinal disorders, as well as an increase in blood levels of certain inflammatory markers. Sixty patients infected with H.pylori was inserted in the current study with age (31.4±3.96) randomly selected from Al Yarmok of Teaching Hospital in Baghdad during April 2015. Patients were diagnosed by using stool antigen and CagAIgG. The medical history was taken, body weight and height were measured and body mass index (BMI) was calculated. Serum Monocyte chemoattractant protein 1 (MCP1) was determined, as well as Interleukin 6 (IL-6) and Fetuin A levels. For comparison, thirty apparently healthy subjects which were matched with patients group for age, weight and BMI (n=30, age=30.5±3.77 years; BMI= 27.13± 2.13 kg/m2; mean±SD). The prevalence of anti H.pylori Cag A-IgG antibodies in patient group (78.3±9.8 U/ml) significantly higher(<0.0001) than healthy subjects group (4.2±2.8 U/ml). H.pylori was capable with a significant rise in the in the inflammatory mediators (fetuin A, MCP1 and IL-6). Fetuin A levels were very highly significant lower(p<0.0001) in patient, group when compared to healthy subjects(29.53±5.25 vs 53. 45±8.37 respectively). The MCP1 levels which significantly increased(p<0.0001)in patient group(48.79±6.03) when compared to control group (37.2±6.85). The mean of IL-6 also shown highly significant difference in patient group when compared to healthy control. The current study also shown there was a positive correlation between MCP1 and IL-6.